NKX2-5 (NK2 transcription factor related, locus 5 (Drosophila).
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چکیده
منابع مشابه
NKX 2 - 5 ( NK 2 transcription factor related , locus 5 ( Drosophila )
Protein Description 324 amino acids; 35-38 kDa, depending on phosphorylation status; contains one TN domain (residues 10-21), one homeodomain (residues 138197), and one NK2 domain (residues 212-234). Expression Expression is mainly restricted to the heart. But during embryogenesis NKX2-5 expression has also been detected in spleen-precursor cells. Localisation Cytoplasmatic and nuclear, probabl...
متن کاملComplex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5
Reversible post-translational protein modifications such as SUMOylation add complexity to cardiac transcriptional regulation. The homeodomain transcription factor Nkx2-5/Csx is essential for heart specification and morphogenesis. It has been previously suggested that SUMOylation of lysine 51 (K51) of Nkx2-5 is essential for its DNA binding and transcriptional activation. Here, we confirm that S...
متن کاملNkx2-5 transcription in heart development
The heart is the first organ to form in mammals. Cardiogenic lineages originate from paired regions of anterior lateral mesoderm, the cardiac crescent, soon after gastrulation and develop into parallel cardiac primordia that fuse to form the primitive heart tube along the ventral midline of the embryo. Subsequent events of looping, chamber maturation and alignment with the vasculature give rise...
متن کاملThe cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.
The tissue-restricted GATA-4 transcription factor and Nkx2-5 homeodomain protein are two early markers of precardiac cells. Both are essential for heart formation, but neither can initiate cardiogenesis. Overexpression of GATA-4 or Nkx2-5 enhances cardiac development in committed precursors, suggesting each interacts with a cardiac cofactor. We tested whether GATA-4 and Nkx2-5 are cofactors for...
متن کاملControl of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic day 7.5 in the mouse and expression is maintained throughout the developing and adult heart. In addition to the heart, Nkx2-5 is transiently expressed in the developing pharynx, thyroid and stomach. To in...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38185